{
  "status": "exploratory development evaluation; previously viewed cells; independent evaluation not completed",
  "join_coverage": {
    "matched": 55,
    "eligible": 55,
    "meaning": "cell identity mapping; not prediction interval coverage"
  },
  "summary": {
    "drug_mean": {
      "MAE": {
        "mean": 0.6079409698275863,
        "median": 0.6029837592364531,
        "min": 0.49925697865353047,
        "max": 0.6800223214285714
      },
      "RMSE": {
        "mean": 0.7979660442002847,
        "median": 0.8076867020516963,
        "min": 0.6574408665693837,
        "max": 0.871645145194509
      }
    },
    "tissue": {
      "MAE": {
        "mean": 0.5946546561906478,
        "median": 0.6009306718509309,
        "min": 0.44086162620220515,
        "max": 0.6662877813625451
      },
      "RMSE": {
        "mean": 0.7839902962858876,
        "median": 0.8026572914275383,
        "min": 0.6009375367736373,
        "max": 0.8608311076184902
      }
    },
    "molecular": {
      "MAE": {
        "mean": 0.5509287944226826,
        "median": 0.5588387287520505,
        "min": 0.40197166758700253,
        "max": 0.6622713418025448
      },
      "RMSE": {
        "mean": 0.7414008580304515,
        "median": 0.7335622639259162,
        "min": 0.5479722863748202,
        "max": 0.8602295268552776
      }
    },
    "delta_vs_drug_mean": {
      "mean": -0.05701217540490358,
      "median": -0.05835274387295791,
      "min": -0.11428517418928064,
      "max": 0.016677605891928127,
      "wins": 19,
      "n_splits": 20
    },
    "delta_vs_tissue": {
      "mean": -0.043725861767965134,
      "median": -0.05190889086407485,
      "min": -0.101035457960641,
      "max": 0.033626676140052325,
      "wins": 18,
      "n_splits": 20
    }
  },
  "runs": [
    {
      "seed": 20262001,
      "counts": {
        "train": 29,
        "calibration": 7,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 100,
        "inner_MAE": 0.48104401168298877
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.6067636494252873,
          "RMSE": 0.8242420252847709
        },
        "tissue": {
          "MAE": 0.6184765102808365,
          "RMSE": 0.8166983284683136
        },
        "molecular": {
          "MAE": 0.5949659304934034,
          "RMSE": 0.7933749425230656
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 2.7908620689655175,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 3.0184978448275865,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 2.4121325114473846,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.01179771893188386,
      "delta_molecular_vs_tissue": -0.023510579787433095
    },
    {
      "seed": 20262002,
      "counts": {
        "train": 28,
        "calibration": 8,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 100,
        "inner_MAE": 0.5363063101508233
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.5983422619047619,
          "RMSE": 0.7799144178367649
        },
        "tissue": {
          "MAE": 0.6146887914540815,
          "RMSE": 0.7769532972121872
        },
        "molecular": {
          "MAE": 0.5459703664778507,
          "RMSE": 0.7151946738158329
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.673178571428571,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.8954330357142855,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.353552259570314,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.05237189542691123,
      "delta_molecular_vs_tissue": -0.06871842497623082
    },
    {
      "seed": 20262003,
      "counts": {
        "train": 28,
        "calibration": 8,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 1,
        "inner_MAE": 0.5316598852808783
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.599203869047619,
          "RMSE": 0.7748627568022944
        },
        "tissue": {
          "MAE": 0.5738428385416667,
          "RMSE": 0.7595049645913943
        },
        "molecular": {
          "MAE": 0.5056352529231982,
          "RMSE": 0.6996082433179847
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.2177857142857142,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.0959553571428575,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.052112495103244,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.0935686161244208,
      "delta_molecular_vs_tissue": -0.06820758561846851
    },
    {
      "seed": 20262004,
      "counts": {
        "train": 29,
        "calibration": 7,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 1,
        "inner_MAE": 0.5170777557445141
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.6368369252873564,
          "RMSE": 0.8410776212851903
        },
        "tissue": {
          "MAE": 0.5912644154121374,
          "RMSE": 0.8011812113325283
        },
        "molecular": {
          "MAE": 0.5225517510980757,
          "RMSE": 0.7179081512905139
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 1.9271724137931043,
          "cell_simultaneous": 0.625,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 1.9312939655172423,
          "cell_simultaneous": 0.5,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 1.9724502626699039,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.11428517418928064,
      "delta_molecular_vs_tissue": -0.06871266431406164
    },
    {
      "seed": 20262005,
      "counts": {
        "train": 28,
        "calibration": 8,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 1,
        "inner_MAE": 0.530845513126142
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.6800223214285714,
          "RMSE": 0.8676557983418646
        },
        "tissue": {
          "MAE": 0.6662877813625451,
          "RMSE": 0.8499089028470818
        },
        "molecular": {
          "MAE": 0.6622713418025448,
          "RMSE": 0.8602295268552776
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.0664999999999996,
          "cell_simultaneous": 0.75,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.316196428571428,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.3256909066641427,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.017750979626026675,
      "delta_molecular_vs_tissue": -0.004016439560000307
    },
    {
      "seed": 20262006,
      "counts": {
        "train": 28,
        "calibration": 8,
        "test": 8
      },
      "selected": {
        "pca_components": 2,
        "alpha": 100,
        "inner_MAE": 0.5119182021768379
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.6633943452380952,
          "RMSE": 0.871645145194509
        },
        "tissue": {
          "MAE": 0.5987324839594929,
          "RMSE": 0.8177539590670992
        },
        "molecular": {
          "MAE": 0.6323591600995452,
          "RMSE": 0.8274352231606283
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.612214285714286,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.8463303571428575,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.102500416706456,
          "cell_simultaneous": 0.75,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.03103518513854997,
      "delta_molecular_vs_tissue": 0.033626676140052325
    },
    {
      "seed": 20262007,
      "counts": {
        "train": 28,
        "calibration": 8,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 1,
        "inner_MAE": 0.5148013323945237
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.5810848214285715,
          "RMSE": 0.7532640433225158
        },
        "tissue": {
          "MAE": 0.5183262745439087,
          "RMSE": 0.7266601113480322
        },
        "molecular": {
          "MAE": 0.5176307837882828,
          "RMSE": 0.645585504224521
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.161714285714286,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.3195089285714285,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.1314849203846205,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.06345403764028879,
      "delta_molecular_vs_tissue": -0.000695490755625916
    },
    {
      "seed": 20262008,
      "counts": {
        "train": 30,
        "calibration": 6,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 1,
        "inner_MAE": 0.4590115460227144
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.6757499999999999,
          "RMSE": 0.845792837563711
        },
        "tissue": {
          "MAE": 0.6420392652894491,
          "RMSE": 0.8041333715225482
        },
        "molecular": {
          "MAE": 0.6000992675552477,
          "RMSE": 0.7887898210333563
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 6,
          "half_width_pGI50": 2.6568666666666667,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 6,
          "half_width_pGI50": 2.5152166666666664,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 6,
          "half_width_pGI50": 2.335043330130735,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.07565073244475218,
      "delta_molecular_vs_tissue": -0.04193999773420143
    },
    {
      "seed": 20262009,
      "counts": {
        "train": 29,
        "calibration": 8,
        "test": 7
      },
      "selected": {
        "pca_components": 5,
        "alpha": 100,
        "inner_MAE": 0.4894995891379338
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.5879055829228244,
          "RMSE": 0.84769621389006
        },
        "tissue": {
          "MAE": 0.610856762877565,
          "RMSE": 0.8513242935717644
        },
        "molecular": {
          "MAE": 0.6045831888147525,
          "RMSE": 0.8573360911822566
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.025379310344827,
          "cell_simultaneous": 0.7142857142857143,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.2573987068965513,
          "cell_simultaneous": 0.8571428571428571,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 1.8371930756535146,
          "cell_simultaneous": 0.7142857142857143,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": 0.016677605891928127,
      "delta_molecular_vs_tissue": -0.006273574062812481
    },
    {
      "seed": 20262010,
      "counts": {
        "train": 29,
        "calibration": 7,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 100,
        "inner_MAE": 0.5070385711138754
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.6320158045977011,
          "RMSE": 0.8512794017520945
        },
        "tissue": {
          "MAE": 0.6021268934729064,
          "RMSE": 0.8115989211799699
        },
        "molecular": {
          "MAE": 0.5623216368598972,
          "RMSE": 0.8025305662963614
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 2.0294482758620696,
          "cell_simultaneous": 0.625,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 2.0854793103448284,
          "cell_simultaneous": 0.75,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 2.0079630939313002,
          "cell_simultaneous": 0.625,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.0696941677378039,
      "delta_molecular_vs_tissue": -0.039805256613009155
    },
    {
      "seed": 20262011,
      "counts": {
        "train": 29,
        "calibration": 7,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 100,
        "inner_MAE": 0.530596521920211
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.5464461206896551,
          "RMSE": 0.7184189535232287
        },
        "tissue": {
          "MAE": 0.5409306767142593,
          "RMSE": 0.7108638750526906
        },
        "molecular": {
          "MAE": 0.4398952187536183,
          "RMSE": 0.6120672260369918
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 2.1926896551724138,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 1.94614039408867,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 2.235955417914923,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.10655090193603683,
      "delta_molecular_vs_tissue": -0.101035457960641
    },
    {
      "seed": 20262012,
      "counts": {
        "train": 29,
        "calibration": 7,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 1,
        "inner_MAE": 0.5378952305717445
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.6445704022988507,
          "RMSE": 0.7619133546331182
        },
        "tissue": {
          "MAE": 0.6101034121636421,
          "RMSE": 0.7429254500680256
        },
        "molecular": {
          "MAE": 0.5553558206442039,
          "RMSE": 0.7149499312043408
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 2.542965517241379,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 2.426683189655172,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 1.9199071787367394,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.0892145816546468,
      "delta_molecular_vs_tissue": -0.0547475915194382
    },
    {
      "seed": 20262013,
      "counts": {
        "train": 30,
        "calibration": 7,
        "test": 7
      },
      "selected": {
        "pca_components": 5,
        "alpha": 100,
        "inner_MAE": 0.5653969424443882
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.5540976190476191,
          "RMSE": 0.698166450245697
        },
        "tissue": {
          "MAE": 0.5819526416001183,
          "RMSE": 0.7177716314027763
        },
        "molecular": {
          "MAE": 0.5200930026469177,
          "RMSE": 0.6879122687912478
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 1.9244666666666665,
          "cell_simultaneous": 0.8571428571428571,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 1.76061875,
          "cell_simultaneous": 0.8571428571428571,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 1.9491545479249446,
          "cell_simultaneous": 0.8571428571428571,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.034004616400701404,
      "delta_molecular_vs_tissue": -0.06185963895320057
    },
    {
      "seed": 20262014,
      "counts": {
        "train": 28,
        "calibration": 8,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 1,
        "inner_MAE": 0.4641324216859603
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.5915550595238096,
          "RMSE": 0.8184079777132515
        },
        "tissue": {
          "MAE": 0.6535755595419986,
          "RMSE": 0.8608311076184902
        },
        "molecular": {
          "MAE": 0.5702290461667487,
          "RMSE": 0.7767236356261511
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.523142857142857,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.4279392857142854,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.3300016775708716,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.021326013357060858,
      "delta_molecular_vs_tissue": -0.0833465133752499
    },
    {
      "seed": 20262015,
      "counts": {
        "train": 28,
        "calibration": 8,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 1,
        "inner_MAE": 0.4812874195565043
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.6285044642857143,
          "RMSE": 0.8488686807759966
        },
        "tissue": {
          "MAE": 0.5997344502289552,
          "RMSE": 0.8327464873154885
        },
        "molecular": {
          "MAE": 0.5506642600202437,
          "RMSE": 0.7811726411822911
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 1.4005,
          "cell_simultaneous": 0.375,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 1.6425910714285719,
          "cell_simultaneous": 0.5,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 1.5478052963054445,
          "cell_simultaneous": 0.625,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.07784020426547056,
      "delta_molecular_vs_tissue": -0.049070190208711506
    },
    {
      "seed": 20262016,
      "counts": {
        "train": 28,
        "calibration": 8,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 100,
        "inner_MAE": 0.5028173614898954
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.6191875000000001,
          "RMSE": 0.7657496130021387
        },
        "tissue": {
          "MAE": 0.6311021868122251,
          "RMSE": 0.7747137124958308
        },
        "molecular": {
          "MAE": 0.5659360498943731,
          "RMSE": 0.6996521070930853
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.018928571428571,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 1.9964624999999998,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 1.7784903818472966,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.05325145010562704,
      "delta_molecular_vs_tissue": -0.065166136917852
    },
    {
      "seed": 20262017,
      "counts": {
        "train": 29,
        "calibration": 7,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 1,
        "inner_MAE": 0.4883427745809019
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.6244985632183908,
          "RMSE": 0.8533317848920288
        },
        "tissue": {
          "MAE": 0.5763133466748769,
          "RMSE": 0.8254662110535277
        },
        "molecular": {
          "MAE": 0.6023856295771685,
          "RMSE": 0.8435840461263114
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 1.838103448275862,
          "cell_simultaneous": 0.5,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 1.6979495073891622,
          "cell_simultaneous": 0.5,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 1.8192711852242587,
          "cell_simultaneous": 0.75,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.022112933641222354,
      "delta_molecular_vs_tissue": 0.026072282902291577
    },
    {
      "seed": 20262018,
      "counts": {
        "train": 29,
        "calibration": 8,
        "test": 7
      },
      "selected": {
        "pca_components": 5,
        "alpha": 100,
        "inner_MAE": 0.5232699695794879
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.5908579638752054,
          "RMSE": 0.7969654263901412
        },
        "tissue": {
          "MAE": 0.5855317459742518,
          "RMSE": 0.7836378572263039
        },
        "molecular": {
          "MAE": 0.500559334719438,
          "RMSE": 0.7067738979126746
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.623137931034483,
          "cell_simultaneous": 0.8571428571428571,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.6603224137931036,
          "cell_simultaneous": 0.8571428571428571,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.5326878850672756,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.09029862915576736,
      "delta_molecular_vs_tissue": -0.0849724112548138
    },
    {
      "seed": 20262019,
      "counts": {
        "train": 29,
        "calibration": 7,
        "test": 8
      },
      "selected": {
        "pca_components": 5,
        "alpha": 1,
        "inner_MAE": 0.5178674611607063
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.598525143678161,
          "RMSE": 0.7826275149869352
        },
        "tissue": {
          "MAE": 0.636345460705834,
          "RMSE": 0.8141946955700616
        },
        "molecular": {
          "MAE": 0.5630971785311404,
          "RMSE": 0.7492163765613185
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 1.9866206896551724,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 2.2434116379310343,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 7,
          "half_width_pGI50": 2.066039117312468,
          "cell_simultaneous": 0.875,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.035427965147020624,
      "delta_molecular_vs_tissue": -0.07324828217469359
    },
    {
      "seed": 20262020,
      "counts": {
        "train": 29,
        "calibration": 8,
        "test": 7
      },
      "selected": {
        "pca_components": 5,
        "alpha": 1,
        "inner_MAE": 0.5699824369661887
      },
      "metrics": {
        "drug_mean": {
          "MAE": 0.49925697865353047,
          "RMSE": 0.6574408665693837
        },
        "tissue": {
          "MAE": 0.44086162620220515,
          "RMSE": 0.6009375367736373
        },
        "molecular": {
          "MAE": 0.40197166758700253,
          "RMSE": 0.5479722863748202
        }
      },
      "intervals": {
        "drug_mean": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.525586206896552,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "tissue": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.414825431034483,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        },
        "molecular": {
          "nominal": 0.8,
          "calibration_cells": 8,
          "half_width_pGI50": 2.2685968484413532,
          "cell_simultaneous": 1.0,
          "status": "descriptive only; exchangeability not established"
        }
      },
      "delta_molecular_vs_drug_mean": -0.09728531106652794,
      "delta_molecular_vs_tissue": -0.03888995861520261
    }
  ],
  "elapsed_seconds": 11.224075416103005,
  "threads": 1,
  "limitations": [
    "no independent data final test; locked cells not evaluated",
    "same overlapping development splits; wins are not independent trials",
    "upstream FPKM normalization is supplied by source; downstream imputation/selection/scaling/PCA fit only training",
    "representative filtering changes cohort; compare only recalculated three models here",
    "aggregate GI50 censoring/conditions unresolved; no clinical efficacy claim"
  ],
  "development_cells": 44,
  "tests": "14 passing tests recorded locally; not CI",
  "freeze": "molecular protocol prospective; imported code/environment additionally locked after result",
  "source": {
    "url": "https://discover.nci.nih.gov/cellminer/download/processeddataset/nci60_RNA__RNA_seq_composite_expression.zip",
    "sha256": "fe0bc1f8fda562c5ebf016c90f29e18bdf3145eebe8fda01365eb03d2200dff1",
    "bytes": 12227542,
    "version": "CellMiner 2.15",
    "genome": "HG-19",
    "source_date_label": "09-11-2025",
    "scale": "log2(FPKM + 1)",
    "gene_records": 23808,
    "cell_columns": 60,
    "missing_values": 0,
    "zero_values": 355270,
    "terms": "https://discover.nci.nih.gov/disclaimer.jsp",
    "redistribution": "not assumed; original matrix stays ignored local cache"
  }
}