{
  "schema_version": 1,
  "kind": "registered descriptive transfer diagnostics v3; already viewed data",
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    "unknown_tissue": {
      "counts": {
        "rows": 592,
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        "known_tissue_models": 0,
        "unknown_tissue_models": 193,
        "known_tissue_rows": 0,
        "unknown_tissue_rows": 592
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        "molecular_vs_tissue_cv": {
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      "per_drug_counts": {
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      "per_drug_status": {
        "123127": "eligible",
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    "bootstrap_known": {
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      "scope": "strict in-range primary cohort",
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      "minimum_valid_fraction": 0.9,
      "macro_drug_sets": "fixed at the original evaluation; all original correlations required per draw",
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    "bootstrap_unknown": {
      "seed": 20266004,
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    "not_in_range_only": {
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            "status": "available"
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        "value": 0.08755157509450123,
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          "123127",
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        "name": "molecular_minus_tissue_fixed",
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            -0.01388902622785804,
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      "bootstrap": {
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        "method": "paired origin-group cluster bootstrap; integer multiplicities; average tied ranks",
        "interval": "95% percentile; descriptive"
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  },
  "context_registered_primary_macro_rho": {
    "molecular": 0.06165163433670498,
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    "tissue_cv": 0.10316803115731037
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  "decision": {
    "reading": "low_response_concordance",
    "tentative": true
  },
  "interpretation_note": "band heuristic, noncausal, no unique attribution",
  "limits": [
    "Already viewed external results; technical re-registration after a preserved timeout, not a new blind test.",
    "Same-cell response concordance is not a mathematical upper bound or identification of a causal obstacle.",
    "Q1 and Q2 use different cohorts; RNA bridge overlaps training and output agreement is not response accuracy.",
    "Known/Unknown and in/out-of-range strata have different populations; correlations do not uniquely identify causes.",
    "Outside-range fits and the NCI top-dose proxy are not source censoring flags.",
    "No model fitting, retuning, favorable drug selection, clinical validation or normal-cell toxicity validation."
  ],
  "distribution": "whitelisted aggregates only; no cell IDs, expression profiles or individual responses/predictions"
}